Pam, we are sure JetPack has nice features and all but it allows you to add a blog / comment subscription module only. On the other hand services like MailChimp and Aweber are professional email service providers offering many powerful features which allow you to really benefit from the email list you are building. As far as simplicity is concerned, we are slightly more inclined towards MailChimp, they have a great user interface even for absolute beginners, they have excellent documentation, and lots of resources to learn how to use each feature available.
You see, the people on your email list are your best customers.  They have visited your site and found it interesting enough to subscribe for more content.  For that reason alone, they are much more likely to listen to any offers you may send them (affiliate promotions, product sales, discount coupons, etc.).  So, having a large email list can actually be quite profitable, which is why bloggers and website owners hold them in such high regard.
However, if you are willing to invest some money in your learning, I would heartily recommend that you stop reading immediately and grab yourself a copy of Start a Blog that Matters. This is an online course developed by the aforementioned Corbett Barr, and I cannot recommend it enough. I have been running through the course material over the last couple of months, and it has revolutionized my approach to blogging (which some of you may well have observed with interest).

On the one hand, I feel angry to be bulked in with all those sites trying to sell “stuff”. BUT, I think that it’s best to be pushy, otherwise people will not think to leave their email. Then they will forget about us when they most need us. I am not selling anything, i just want to increase online communication between suffers of a specific chronic illness. Whether i obtain sponsorship from medical device companies is not sure.
Very nice comparison of Mailchimp and Aweber. It looks like both Aweber and Mailchimp will suspend you without notice for seemingly trivial reasons. I think it is always good to have a backup system of your own. I use autoresponderplus and 12all scripts and have backups of my campaigns. Aweber is a great service you just never no when you might offend them. It seems like Mailchimp is even touchier. I think the best solution is not to rely completely on any one service. Nice post!
AWeber finds a healthy balance between ease of use and robust functionality. There are some nice features — particularly in the autoresponder realm — but navigation is intuitive enough that I was able to perform basic tasks without looking up tutorials. When I did find myself at a loss and turned to the online help resources, I was quite impressed with the range and scope of guidance available.
Now, you can automatically send highly relevant emails encouraging them to buy the product or service they were considering. Customers who received multiple abandoned shopping cart emails are 2.4 times more likely to complete the purchase than those who receive only one followup email, according to Experian. Try sending the first message one day after, a second message 48 hours after, and possibly a third message within three or four days of abandonment.
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